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They started their quest to defend their Wimbledon Ladies' doubles title by beating fellow American Julie Ditty and the Czech Republic's Renata Voracova. They went down in straight sets 6-4, 6-2.
The number one doubles seeds will face Timea Bacsinszky of Switzerland and Tathiana Garbin of Italy in the second round.
Big Sis handled her Centre Court business in her second round singles match versus Russia's Ekaterina Makarova. The tournament second seed took out Makarova 6-0, 6-4 and will face another Russian, Alisa Kleybanova in her third round match.