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She had a match point in the third set that sailed an inch wide, and Stosur capitalized on it to break serve for a 7-6 lead. She then closed out the match with three service winners to hand Serena her first Grand Slam tournament loss since last year's US Open semifinal.
Serena was trying to reach her first French Open singles final since 2003 and was trying for a calendar year Grand Slam.
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Serena dusted herself off after her loss and joined Big Sis an hour later for a hard fought 2 hour three set win over American Liezel Huber and Anabel Medina Garrigues of Spain 2-6, 6-2, 6-4 to reach the French Open doubles final for the first time since 1999.
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With their semifinals win, the Williams sisters are now the Number one ranked doubles team in the world irregardless of the results of the doubles final.
Serena is also the first player since Kim Clijsters accomplished the feat in 2003 to hold Number one world rankings simultaneously in singles and doubles.
Should Team Williams be successful in capturing the French Open doubles title, they would be halfway to completing a doubles Grand Slam.