In their only meeting at Wimbledon until today, Maria Sharapova upset Serena Williams for the 2004 Wimbledon Ladies' singles title.
Things are much different now as they faced each other once again on Centre Court in the fourth round of this year's tournament.
It took Little Sis an hour and 35 minutes, three saved set points, 19 aces and 31 winners, but she eventually subdued the 16th seed Sharapova 7-6 (11-9), 6-4 and move on to a quarterfinal matchup with China's Li Na.
If Serena gets past Li Na, she would take on the winner of the Petra Kvitova-Kala Kanepi match. Kvitova upset third seed Caroline Wozniacki of Denmark in straight sets while Estonia's Kanepi is a qualifier on a little bit of a giant killing roll herself.
Number 2 seeded Big Sis was busy on the other side of the bracket subduing Australia's Jarmila Groth in a 6-4, 7-6 (7-5) straight set victory to advance to a quarterfinal round match with Bulgaria's Tsvetana Pironkova.
If Big Sis gets past her, she'd have a tougher semifinal match to get through. She would have to take on the winner of the Kim Clijsters-Vera Zvonareva match.
The Williams sisters are moving on to the quarterfinals in the Ladies' doubles competition as well after beating Slovakia's Dominika Cibulkova and Anastasia Pavlyuchenkova of Russia in straight sets 6-2, 6-1.
The Number one doubles seeds and World number one's have yet to drop a set in this 2010 Ladies' doubles tournament.