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At one point during this wild game UH held a commanding 40-22 lead with 12:25 left, but two Southern Miss touchdown passes from Martevious Young to wide receiver Gerald Baptiste in a span of 5:25 tied the game with 57 seconds left.
It took Heisman Trophy candidate Case Keenum throwing for a personal best 559 yards and five TD's, a 48 yard touchdown throw to Patrick Edwards with 21 seconds remaining to break the tie, and the defense swatting down a Southern Mississippi Hail Mary pass in the end zone to preserve the 50-43 win over one of the C-USA East Division co-leaders.
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In addition to the offensive fireworks Keenum provided, the Cougars racked up a season-high 750 yards of total offense as they bumped their season record to 7-1 for the year and 3-1 in C-USA West play.
Next up are road games versus Tulsa and UCF before they return to Robertson Stadium and finish the season at home against Memphis and Rice.